Proof of Concept in LOX-1–Knockout Mice
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چکیده
Knockout Mice − LOX-1 and Atherosclerosis : Proof of Concept in LOX-1 Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2007 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/CIRCRESAHA.107.101105 2007;100:1534-1536 Circ Res. http://circres.ahajournals.org/content/100/11/1534 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
LOX-1 and atherosclerosis: proof of concept in LOX-1-knockout mice.
An increased plasma level of low-density lipoprotein (LDL) is a well-known risk factor for endothelial dysfunction and atherosclerosis.1 The proatherosclerotic potential of LDL may even increase after oxidative modification to oxidized LDL (oxLDL),2 whose uptake by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of atherosclerotic lesio...
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Angiotensin II via type 1 receptor activation upregulates the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and LOX-1 activation, in turn, upregulates angiotensin II type 1 receptor expression. We postulated that interruption of this positive feedback loop might attenuate the genesis of angiotensin II-induced hypertension and subsequent cardiac remodeling. To ex...
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BACKGROUND/AIMS Although individual contributions of TNF-α, LOX-1 and adiponectin to the regulation of endothelial function were previously studied, their interactions in the regulation of coronary endothelial function remain unclear. The aim of this study is to investigate the interactions between TNF-α, LOX-1 and adiponectin in endothelial dysfunction in atherosclerosis. METHODS Vasodilator...
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We hypothesized that the reciprocal association between adiponectin and lectin-like oxidized LDL (ox-LDL) receptor (LOX)-1 contributes to the regulation of aortic endothelial dysfunction in atherosclerosis. To test this hypothesis, endothelium-dependent (ACh) and endothelium-independent (sodium nitroprusside) vasorelaxation of isolated aortic rings from control mice, apolipoprotein E (ApoE) kno...
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تاریخ انتشار 2007